Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)

Study Website

PI(s): Matthew Roe, MD, Duke University

Study Design: Pragmatic Randomized Clinical Trial

Project Summary: Clinicians often prescribe aspirin to prevent strokes and heart attacks in people living with heart disease. Research has yet to determine the best dose to use to get maximum benefit while minimizing risks, like increased bleeding. ADAPTABLE researchers will look at benefits and side effects not just overall, but also by gender, age, ethnicity, and race, as well as in patients with medical conditions in addition to heart disease, such as diabetes. It’s a far cry from traditional studies that assess what works for the "average" patient. Patients who have heart disease and are at high risk of having a heart attack or stroke will be randomly assigned to use low or regular strength aspirin and followed for up to 30 months.

PaTH Partners:

  • Johns Hopkins University (Dan Ford, Site PI)
  • Ohio State University (Brent Lampert, Site PI)
  • Penn State University (Jennifer L. Kraschnewski, Site PI)
  • Temple University (Anuradha Paranjape, Site PI)
  • University of Pittsburgh (Sandeep K. Jain, Site PI)

PCORnet Partners:

  • Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN)
  • Greater Plains Collaborative CDRN, based at the University of Kansas Medical Center, Kansas City, University of Utah, University of Utah Health
  • REACHnet Research Action for Health Network, Louisiana Public Health Institute
  • Mid-South CDRN, based at Vanderbilt University, Nashville, Tennessee
  • New York City CDRN, based at Weill Medical College of Cornell University
  • pSCANNER: Patient-centered SCAlable National Network for Effectiveness Research, University of California, San Diego
  • The Health eHeart Alliance PPRN, University of California, San Francisco
  • OneFlorida Clinical Research Network, University of Florida

Sponsor: PCORI®

Coordinating Center: Duke University Clinical Research Institute

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