A Prospective, Observational Study of Participants with Major Depressive Disorder who have an Inadequate Response to an Antidepressant

PI(s): Anne Marie Gebara, University of Pittsburgh Medical Center

Project Summary: This is a prospective, multicenter, 2-year observational study (non-interventional), in adult (18-64 years) and elderly (65-74 years) participants with Major Depressive Disorder (MDD) who have had insufficient response to an antidepressant. Data will be collected continuously from the electronic health records (EHR) starting at baseline (start of the adjunctive treatment or antidepressant medication switch) for 2 years and/or from regularly scheduled clinical outcome assessments (patient-reported outcomes [PRO] and clinician-reported outcomes [ClinROs]) approximately every 3-6 months. The treatment decision (for adjunctive treatment or antidepressant medication switch) must have been taken prior to and independently of the participant’s inclusion in the study. Additionally, participating clinicians will be asked to obtain clinical outcomes assessment data from participants within this study as possible.