Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine Trial (HERO-HCQ Trial)

Project Summary:

  • The HERO Registry invites healthcare workers across the nation to join together to share their experiences and needs to address the COVID-19 pandemic
  • By understanding their concerns and interests, we can rapidly generate much needed evidence to help protect them—their health and well-being
  • The HERO Registry is at the ready to engage participants in rapid research for potential protective therapies (e.g. hydroxychloroquine, vaccines, etc.)
  • Joining is easy – just click on the link and complete the online form to join. Participants are invited to answer short surveys and will have the option to participate in future clinical studies. The HERO Registry can also be used to learn results from HERO research and share ideas about problems that need to be addressed and research that is needed to fight COVID.

HERO Website:

Why Create a Community of Healthcare Workers?

  • Healthcare workers are on the front lines of our nation’s war with COVID-19
  • Their duty is to protect and treat us all
  • But on the front lines, they are more at risk, both physically and mentally, to the toll the pandemic poses (personally & with their families)
  • We need evidence to keep healthcare workers and their families safe and healthy, which ultimately will help protect us all

PI(s): Adrian Hernandez, MD, Duke Clinical Research Institute; Susanna Naggie, MD, Duke Clinical Research Institute

PaTH Protocol PI(s): Alison Morris, MD, University of Pittsburgh School of Medicine; Kathleen Mctigue, MD, University of Pittsburgh School of Medicine

Purpose: The purpose of this study is to evaluate the efficacy of HCQ to prevent COVID-19 clinical infection in healthcare workers (HCWs) as well as to evaluate the efficacy of HCQ to prevent viral shedding of SARS-CoV-2 among HCWs and the safety and tolerability of HCQ.

Goal(s): HERO is a research program – short for Healthcare Worker Exposure Response & Outcomes (HERO) – that will unite healthcare workers across America to study and address the problems our healthcare heroes face in real time—and over time.

The HERO program will initially have two parts – the HERO Registry and the HERO-HCQ Trial. In the future, the HERO Registry will help speed additional clinical studies that address unmet needs for healthcare workers.

Study Design: Clinical Trial and Registry

PaTH Partners: Johns Hopkins University/Johns Hopkins Health System, Geisinger Health, Penn State College of Medicine/Penn State Milton S. Hershey Medical Center, Temple Health System/Lewis Katz School of Medicine at Temple University, the University of Pittsburgh/UPMC the Ohio State University/Ohio State University Wexner Medical Center, and the University of Michigan/Michigan Medicine.

Sponsor: Patient-Centered Outcomes Research Association (PCORI)

Coordinating Center: Duke Clinical Research Institute

How to Participate: The HERO Registry is open to all healthcare workers, including nurses, therapists, physicians, emergency responders, food service workers, environmental service workers, interpreters, transporters — anyone who works in a setting where people receive health care.

To join, participants must be:

  • A U.S. healthcare worker in any profession
  • ≥ 18 years old

You can use a work email address, gmail address, or another email address to sign up:

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